Pierre Fabre Laboratories and Scorpion Therapeutics Announce First Patient Dosed in Phase I / II Clinical Trial of PFL-241 / STX-241, a Mutant-Selective Inhibitor Intended To Treat Locally Advanced or Metastatic Non-Small Cell Lung Cancer

Pierre Fabre Laboratories Italy United States of America Canada France Germany Spain United Kingdom Massachusetts California

The PFL-241/STX-241 Phase I/II trial is an open label, multi-center study that aims to assess the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD) and preliminary clinical efficacy of PFL-241/STX-241 as a monotherapy in patients with locally advanced or metastatic non-small cell lung cancer ("NSCLC") harboring EGFR Exon 19 or 21 mutations with the co-occurring C797S mutation.

NSCLC is the most common form of lung cancer and EGFR mutations are one of its most common disease drivers, occurring in up to 38 percent of tumors, depending on geography1,2,3.

"We are eager to begin the clinical evaluation of PFL-241/STX-241, our mutant-selective 4th generation EGFR inhibitor, a molecule with differentiated properties that we believe has the potential to become a best-in-class therapeutic option for patients developing resistance to current targeted therapy," said Francesco Hofmann, Head of Research and Development for Medical Care at Pierre Fabre Laboratories. "The initiation of this clinical trial highlights our team's engagement and execution in strong partnership with Scorpion Therapeutics, and we look forward to demonstrating how patients could potentially benefit from this targeted therapy."

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Pierre Fabre Laboratories Media Contact:

Laure Bregeon-Sgandurra
Pierre Fabre Laboratories
[e-mail] 

Scorpion Therapeutics Contacts: 
Media Contact:
Ethan Metelenis
Precision AQ
[e-mail] 

Investor Contact:
Emiley Demick
Precision AQ
[e-mail] 

 

 

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