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New, Data

The Janssen Pharmaceutical Companies of Johnson & Johnson today announced results from a post-hoc pooled analysis of the Phase 3 GRIPHON and Phase 3b TRITON clinical trials evaluating the impact of early initiation of UPTRAVI® (selexipag) on disease progression, in a large population of PAH patients.

30.08.2021 - 07:17:19

New Data Demonstrate the Benefits of Early Use of UPTRAVI® in Delaying Disease Progression in a Broad Population of Patients with Pulmonary Arterial Hypertension

or on request from Johnson & Johnson. None of the Janssen Pharmaceutical Companies nor Johnson & Johnson undertakes to update any forward-looking statement as a result of new information or future events or developments.

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References

1 Coghlan GJ, Gaine S, Channick RN, et al. Treatment effect of selexipag on time to disease progression when initiated early in pulmonary arterial hypertension (PAH) patients: GRIPHON and TRITON pooled analysis. Abstract of presentation at European Society of Cardiology (ESC) Congress, 27-30 August 2021.
2 Coghlan GJ, Gaine S, Channick RN, et al. Treatment effect of selexipag on time to disease progression when initiated early in pulmonary arterial hypertension (PAH) patients: GRIPHON and TRITON pooled analysis. Oral presentation at European Society of Cardiology (ESC) Congress, 27-30 August 2021.
3 Vachiery JL, Gaine S. Challenges in the diagnosis and treatment of pulmonary arterial hypertension. Eur Respir Rev. 2012;21:313-320.
4 Galiè N, Humbert M, Vachiery JL, et al. 2015 ESC/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension. Eur Heart J. 2016;37:67-119.
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7 Sitbon O, Channick R, Chin KM, et al. Selexipag for the treatment of pulmonary arterial hypertension N Engl J Med. 2015;373:2522–2533.
8 Chin KM, Sitbon O, Doelberg M, et al. Efficacy and safety of initial triple oral versus initial double oral combination therapy in patients with newly diagnosed pulmonary arterial hypertension (PAH): results of the randomized controlled TRITON study. Am J Respir Crit Care Med. 2020;201:A2928.
9 ClinicalTrials.gov. The efficacy and safety of initial triple versus initial dual oral combination therapy in patients with newly diagnosed pulmonary arterial hypertension (TRITON). NCT02558231. Available at: https://clinicaltrials.gov/ct2/show/NCT02558231 Last accessed August 2021.
10 McLaughlin VV, Archer SL, Badesch DB, et al. ACCF/AHA 2009 expert consensus document on pulmonary hypertension. Circulation. 2009;119:2250-2294.
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12 Chin KM, Maitland MG, Channick RN, et al. Psychometric validation of the Pulmonary Arterial Hypertension-Symptoms and Impact (PAH-SYMPACT) questionnaire: results of the SYMPHONY trial. Chest. 2018:154:848-861.
13 Armstrong I, Billings C, Kiely DG, et al. The patient experience of pulmonary hypertension: a large cross sectional study of UK patients. BMC Pulm Med. 2019;19:67.
14 Uptravi Summary of Product Characteristics. March 2021. Available at: https://www.ema.europa.eu/en/documents/product-information/uptravi-epar-product-information_en.pdf Last accessed August 2021.
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16 Jnj.com. UPTRAVI ® (selexipag) Receives FDA Approval for Intravenous Use in Adult Patients with Pulmonary Arterial Hypertension (PAH). Available at: https://www.jnj.com/uptravi-selexipag-receives-fda-approval-for-intravenous-use-in-adult-patients-with-pulmonary-arterial-hypertension-pah Last accessed: August 2021.

EM-71235
August 2021

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