New Data from Esketamine Nasal Spray Phase 3 Studies Showed Rapid Reduction of Depressive Symptoms in Adult Patients with Major Depressive Disorder Who Have Active Suicidal Ideation with Intent. These studies were presented at the 32nd European College of Neuropsychopharmacology (ECNP), taking place September 7–10 in Copenhagen.
[i] Fu DJ, et al. Esketamine nasal spray for rapid reduction of major depressive disorder symptoms in patients at imminent risk for suicide. ASPIRE-1 study. Poster P323 presented at ECNP 2019, 7–10 September, Copenhagen, Denmark.
[ii] Ionescu DF, et al. Esketamine nasal spray for rapid reduction of major depressive disorder symptoms in patients at imminent risk for suicide. ASPIRE-2 study. Poster P607 presented at ECNP 2019, 7–10 September, Copenhagen, Denmark.
[iii] Haggerty, J. PsychCentral.com. An Overview of Depression Treatment Options. Available at: https://psychcentral.com/lib/an-overview-of-depression-treatment-options/. (last accessed September 2019).
[iv] Popova V, et al. Am J Psychiatry 2019. doi: 10.1176/appi/ajp.2019.19020172 [Epub ahead of print].
[v] Daly E, et al. JAMA Psychiatry 2019. doi: 10.1001/jamapsychiatry.2019.1189 [Epub ahead of print].
[vi] Wajs E, et al. Poster T67 presented at ASCP 2018, 29 May–01 June, Miami, Florida.
[vii] Fedgchin M, et al. Int J Neuropsychopharmacol. 2019 Jul 10. pii: pyz039. doi: 10.1093/ijinp/pyz039. [Epub ahead of print]
[viii] Ochs-Ross R, et al. Poster W27 presented at ASCP 2018, 19 May–01 June, Miami, Florida.
[ix] Janssen. Press Release March 2019. Janssen Announces U.S. FDA Approval of SPRAVATO™ (esketamine) CIII Nasal Spray for Adults with Treatment-Resistant Depression (TRD) Who Have Cycled Through Multiple Treatments Without Relief. Available at: https://www.janssen.com/janssen-announces-us-fda-approval-spravato-esketamine-ciii-nasal-spray-adults-treatment-resistant. (last accessed September 2019).
[x] Johnson & Johnson Ltd. Press Release August 2016. Esketamine Receives Breakthrough Therapy Designation from U.S. Food and Drug Administration for Major Depressive Disorder with Imminent Risk for Suicide. Available at: https://www.jnj.com/media-center/press-releases/esketamine-recieves-breakthrough-therapy-designation-from-us-food-and-drug-administration-for-major-depressive-disorder-with-imminent-risk-of-suicide. (last accessed September 2019).
[xi] Johnson & Johnson Ltd. Press release October 2018. Janssen Submits European Marketing Authorisation Application for Esketamine Nasal Spray for Treatment-Resistant Depression. Available at: https://www.jnj.com/janssen-submits-european-marketing-authorisation-application-for-esketamine-nasal-spray-for-treatment-resistant-depression. (last accessed September 2019).
[xii] World Health Organization. Depression. Available at: https://www.who.int/en/news-room/fact-sheets/detail/depression. (last accessed September 2019).
[xiii] Bachmann S. Int J. Environ. Res. Public Health 2018 Jul 6; 15(7). Pii: E1425. doi: 10.3390/ijerph15071425.