BonAlive Fighting

Antibiotic resistance is estimated to have caused the death of over 700 000 patients worldwide last year.

08.03.2017 - 07:02:01

BonAlive: Fighting antibiotic resistance with glass. In 2050, this number is forecast to rise to 10 million1. As antibiotics are losing their effect at alarming speed new alternatives are being evaluated. According to a recent study, naturally antibacterial bioactive glass has shown excellent results for bone infections – without local antibiotics.

Chronic osteomyelitis is a severe bacterial disease, which can appear anywhere in the skeleton and is typically caused by trauma or reduced biologics, e.g. due to diabetes. In the worst case, it might lead to amputation. As demonstrated in the 116-patient study, bioactive glass can effectively reduce the number of procedures to only one. This is a significantly more comfortable treatment method for the patient and saves healthcare costs. Over time the glass will be replaced by bone.

“According to the results, more than 90 percent of the cases achieved a long-lasting infection control with only one surgical procedure. This is a notable result, considering that most of the treated patients underwent several failed surgical attempts.”, says Prof. Carlo L. Romanò, orthopedic surgeon and Director of the Center for Reconstructive Surgery of Bone and Joint Infections, Galeazzi Orthopaedic Institute, Milan.

According to Prof. Lorenzo Drago, Head of Laboratory Analysis, Galeazzi Orthopaedic Institute, Milan; Italy is considered a high-risk country for the increasing threat of antibiotic resistance. Drago suggests, however, that bioglass poses new possibilities in reducing local antibiotics in septic bone surgery: “The particular way in which bioglass works should make it impossible to induce any resistance by microorganisms.”

Increasing need for antibiotic-free alternatives

BonAlive bioactive glass S53P4 was initially developed in Finland and has a two-decade-long history of patient use.

“To overcome the reliance on antibiotics, collaboration is needed on all levels of society. In addition to regenerating new bone, bioactive glass is able to inhibit bacterial growth without local antibiotics. This is a significant step forward compared to the conventional treatment”, says CEO of BonAlive Biomaterials, Dr. Fredrik Ollila.

BonAlive bioactive glass S53P4 is a bone graft substitute that stimulates new bone growth and protects the surgical site from bacterial growth. The product received an indication approval in 2011 for bone cavity filling in the treatment of chronic osteomyelitis. Bioactive glass is used in neuro, trauma, orthopedic and ear surgery for both adults and children. Last year, BonAlive bioactive glass was used in nearly 10 000 operations around the world.

1 Tackling drug-resistant infections globally: final reports and recommendations, The Review on Antimicrobial Resistance, 05/2016.

2 Adv Exp Med Biol. 2017 Jan 4. doi: 10.1007/5584_2016_156. [Epub ahead of print]

The study abstract is available at:

BonAlive Biomaterials Ltd represents the development of novel antibiotic-free innovations for bone regeneration. The company manufactures and sells implantable biomaterials for bone regeneration used for surgical treatment of chronically infected bone, spine fusions and bone cavity filling. BonAlive® products are available in Europe, the Middle East, Asia-Pacific, Africa and South America. The clinical use of BonAlive® is supported by a twenty-year history of research and more than fifty scientific papers.



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