Heidelberg Pharma and Indiana University Publish Results on HER2-ATAC for Targeted Immunotherapy of Triple Negative Breast Cancer in Science Translational Medicine
In the preclinical study, Trastuzumab-ATAC exhibited superior efficacy in treating HER2-low TNBC with a 17p deletion. Further, Trastuzumab-ATAC induced an immunogenic cell death of the tumor cells, a type of cell death that elicits an immune response. As a consequence, when combined with immune checkpoint blockade therapy in preclinical HER2-low breast cancer models mimicking TNBC, the efficacy of the Trastuzumab-ATAC treatment was greatly increased.
Andreas Pahl, Chief Scientific Officer at Heidelberg Pharma, commented: "We are delighted with the publication of these extraordinary data in the Science Translational Medicine journal. The Trastuzumab-ATAC is a novel treatment strategy in TNBC, an indication with high medical need. These patients do not benefit from currently available anti-hormonal or trastuzumab-based therapies because the tumors lack estrogen or progesterone receptors and also show very low expression of the HER2 protein, which is insufficient for approved HER2-targeting drugs. The synergies of our ATAC technology in combination with checkpoint inhibitors further highlights the potential of ATACs in the treatment of solid tumors."
The report abstract can be accessed at Science Translational Medicine.
About Heidelberg Pharma's proprietary ATAC technology
Antibody Drug Conjugates (ADCs) combine the high affinity and specificity of antibodies with the potency of cytotoxic small molecules for the treatment of cancer. Antibody Targeted Amanitin Conjugates (ATACs) are ADCs whose active ingredient is made up of Amanitin molecules. Amanitins are small bicyclic peptides naturally occurring in the death cap mushroom. They inhibit mRNA transcription by binding to RNA polymerase II, a mechanism that is crucial for the survival of eukaryotic cells. In preclinical testing, ATACs have been shown to be highly efficacious, overcoming frequently encountered resistance mechanisms and combating even quiescent tumor cells.
About Heidelberg Pharma
Heidelberg Pharma is an oncology company and the first company to develop the toxin Amanitin into cancer therapies using its proprietary Antibody Targeted Amanitin Conjugate (ATAC) technology and to advance the biological mode of action of the toxin as a novel therapeutic principle. This proprietary technology platform is being applied to develop the Company's proprietary therapeutic ATACs as well as in third-party collaborations to create a variety of ATAC candidates. The proprietary lead candidate HDP-101 is a BCMA ATAC for multiple myeloma.
Heidelberg Pharma AG has entered into partnerships to further develop and commercialize its clinical assets upamostat (formerly MESUPRON(R)) and TLX250-CDx (formerly REDECTANE(R)). Heidelberg Pharma AG is listed on the Frankfurt Stock Exchange: ISIN DE000A11QVV0 / WKN A11QVV / Symbol HPHA. More information is available at www.heidelberg-pharma.com.
Contact Heidelberg Pharma AG Corporate Communications Sylvia Wimmer Tel.: +49 89 41 31 38-29 Email: investors[at]hdpharma.com Gregor-Mendel-Str. 22, 68526 Ladenburg IR/PR support MC Services AG Katja Arnold (CIRO) Managing Director & Partner Tel.: +49 89 210 228-40 Cell: +49 (0)160 9360 3022 Email: katja.arnold[at]mc-services.eu ?
This communication contains certain forward-looking statements relating to the Company's business, which can be identified by the use of forward-looking terminology such as "estimates", "believes", "expects", "may", "will" "should" "future", "potential" or similar expressions or by a general discussion of the Company's strategy, plans or intentions. Such forward-looking statements involve known and unknown risks, uncertainties and other factors, which may cause our actual results of operations, financial condition, performance, or achievements, or industry results, to be materially different from any future results, performance or achievements expressed or implied by such forward-looking statements. Given these uncertainties, prospective investors and partners are cautioned not to place undue reliance on such forward-looking statements. We disclaim any obligation to update any such forward-looking statements to reflect future events or developments. https://www.nature.com/articles/nature14418
11.02.2021 Dissemination of a Corporate News, transmitted by DGAP - a service of EQS Group AG.The issuer is solely responsible for the content of this announcement.The DGAP Distribution Services include Regulatory Announcements, Financial/Corporate News and Press Releases. Archive at www.dgap.deLanguage: English Company: Heidelberg Pharma AG Gregor-Mendel-Str. 22 68526 Ladenburg
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