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RELIEF THERAPEUTICS Holding AG, CH0100191136

RELIEF THERAPEUTICS Holding AG, CH0100191136

30.09.2021 - 07:19:16

EQS-Adhoc: Relief Reports that U.S. Collaboration Partner Announced Second Favorable Safety Report for ZYESAMI in NIH Sponsored ACTIV-3b Critical Care Study in Life-Threatening COVID-19

Relief Reports that its U.S. Collaboration Partner has Announced a Second Favorable Safety Report for ZYESAMI(TM) (RLF-100(TM)/aviptadil) in the NIH Sponsored ACTIV-3b Critical Care Study in Patients with Life-Threatening COVID-19 ?

Geneva, Switzerland, September 30, 2021 - RELIEF THERAPEUTICS Holding SA (SIX: RLF, OTCQB: RLFTF) ("Relief"), a biopharmaceutical company seeking to provide patients therapeutic relief from serious diseases with high unmet need, reported today that the parent company of its U.S. collaboration partner, NRx Pharmaceuticals, Inc., (Nasdaq: NRXP) ("NRx"), has issued a press release providing a safety update on ZYESAMI(TM) (RLF-100(TM)/aviptadil) which is being tested in the ACTIV-3b/TESICO (Therapeutics for Severely Ill Inpatients with COVID-19) phase three study sponsored by the National Institutes of Health (NIH). According to the press release, in its second scheduled analysis, the study's Independent Data Safety Monitoring Board found no new safety concerns after reviewing a total of 231 patients and recommended continued enrollment. The related NRx press release can be accessed through the following link.

ABOUT RELIEF

Relief focuses primarily on clinical-stage programs based on molecules with a history of clinical testing and use in human patients or a strong scientific rationale. Relief's lead drug candidate, RLF-100(TM) (aviptadil), a synthetic form of Vasoactive Intestinal Peptide (VIP), is in late-stage clinical testing in the U.S. for the treatment of respiratory deficiency due to COVID-19. As part of its pipeline diversification strategy, in March 2021, Relief entered into a Collaboration and License Agreement with Acer Therapeutics for the worldwide development and commercialization of ACER-001. ACER-001 is a taste-masked and immediate release proprietary powder formulation of sodium phenylbutyrate (NaPB) for the treatment of Urea Cycle Disorders and Maple Syrup Urine Disease. In addition, Relief's recently completed acquisitions of APR Applied Pharma Research SA and AdVita Lifescience GmbH, bring to Relief a diverse pipeline of marketed and development-stage programs.

RELIEF THERAPEUTICS Holding SA is listed on the SIX Swiss Exchange under the symbol RLF and quoted in the U.S. on OTCQB under the symbol RLFTF. For more information, visit www.relieftherapeutics.com. Follow us on LinkedIn. ?

CONTACT: RELIEF THERAPEUTICS Holding SA Jack Weinstein Chief Financial Officer and Treasurer contact@relieftherapeutics.com FOR MEDIA/INVESTOR INQUIRIES: Rx Communications Group Michael Miller +1-917-633-6086 mmiller@rxir.com

Disclaimer: This communication expressly or implicitly contains certain forward-looking statements concerning RELIEF THERAPEUTICS Holding SA. Such statements involve certain known and unknown risks, uncertainties and other factors, including (i) whether RLF-100TM (aviptadil) will ever be approved in the U.S., the U.K., or the E.U. for the treatment of respiratory failure in patients with COVID-19, (ii) whether RELIEF THERAPEUTICS Holding SA can satisfactorily resolve its ongoing disputes with NeuroRx without litigation, (iii) whether RELIEF THERAPEUTICS Holding SA will prevail in any litigation action with NeuroRx over the terms of the Collaboration Agreement, and (iv) those risks discussed in RELIEF THERAPEUTICS Holding SA's press releases and filings with the SIX, which could cause the actual results, financial condition, performance or achievements of RELIEF THERAPEUTICS Holding SA to be materially different from any future results, performance or achievements expressed or implied by such forward-looking statements. RELIEF THERAPEUTICS Holding SA is providing this communication as of this date and do not undertake to update any forward-looking statements contained herein as a result of new information, future events or otherwise.

End of ad hoc announcement Language: English Company: RELIEF THERAPEUTICS Holding AG Avenue de S?cheron 15 1202 Gen?ve

Switzerland E-mail: contact@relieftherapeutics.com Internet: https://relieftherapeutics.com ISIN: CH0100191136 Listed: SIX Swiss Exchange EQS News ID: 1236979 ? End of Announcement EQS Group News Service

1236979??30-Sep-2021?CET/CEST

@ dgap.de