Biofrontera AG / Capital increase / Ad hoc: Biofrontera AG determines conditions of the capital increase decided by the share holder meeting on August 18, 2009 Ad hoc announcement according to §15 WpHG processed and transmitted by Hugin. The issuer is solely responsible for the content of this announcement.

Leverkusen, 20 November 2009 - Biofrontera AG's share holder meeting of August 28, 2009 decided to increase the base capital of the company by up to ¤ 2,868,314.00 through issuing up to 2,868,314 new name shares.

Management and supervisory board have today, based on the authorization, determined the details of the capital increase.

The purchase price was fixed at ¤ 2.50.

The shareholders will be offered a purchase right in a 2 : 1 relation in the form that CONRAD HINRICH DONNER BANK Aktiengesellschaft, Hamburg, has been selected to take over the shares, with the obligation to transfer them to the owners of purchase rights, insofar as those have exercised their rights within a period of two weeks.

Shares not drawn by the holders of purchase rights will be issued within a private placement. The detailed purchase offer will be communicated in the electronic Federal Bulletin on November 23, 2009.

The proceeds will be used for Biofrontera's operation. In particular, they will be utilized to forward Biofrontera's clinical product candidate BF-200 ALA into the European registration process within the coming year. With a full placement of all offered shares and fulfillment of the company's sales expectations, the funding should allow the business to reach the anticipated break-even point.

Biofrontera AG, Hemmelrather Weg 201, 51377 Leverkusen, Germany ISIN: DE0006046113, WKN: 604611

Contact: Anke zur Mühlen Biofrontera AG Tel.: 49 (0214) 87 63 222 Fax.: 49 (0214) 87 63 290 E-mail: a.zurmuehlen@biofrontera.com

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Biofrontera AG Hemmelrather Weg 201 Leverkusen Germany

WKN: 604611; ISIN: DE0006046113; Listed: Freiverkehr in Börse Berlin, Freiverkehr in Bayerische Börse München, Freiverkehr in Börse Stuttgart, Open Market (Freiverkehr) in Frankfurter Wertpapierbörse, Regulierter Markt in Börse Düsseldorf;